South Lancashire and Cheshire Division Two leaders Douglas face a tough test to stay top, away to title and promotion rivals Crewe and Nantwich this afternoon (Saturday).
The sides met two weeks ago at Port-e-Chee when a late try earned the Manx side a 5-5 draw.
Vagabonds are also in action off the Island, at Oldershaw.
Ramsey welcome Ellesmere Port to Mooragh Park having convincingly won away to the same opponents a fortnight ago, and held Douglas to a draw last Saturday.
Vagabonds ladies will be out to gain their first points of the season at Eccles.
FC Isle of Man torn apart at Barnoldswick Town
New padel courts in Noble's Park opening after two years in development
Hockey: Compact mixed schedule on the cards this weekend
Rugby: Busy triple-header beckons at Ballafletcher