Holders Corinthians launched their defence of the FloodlIt Cup on Sunday with a 4-0 win against Peel.
After a goalless first half, Kiera Morgan, Lauren Christian, Jenna McStay and Alsivarne McGregor were all on target in the Warehouse Fitness Gym sponsored competition.
In the remaining Group B match, DHSOB edged past Colby 3-2.
With the scores level at 1-1 at half-time, Maria Coulter, Hattie Castle and Rachael Christian netted for the Blackberry Lane side.
The southerners replied via strikes from Courtney Goldsmith and Chloe Swales.
Commonwealth Games athletics squad in positive mood ahead of Glasgow
FC Isle of Man get pre-season underway with summer festival
Swimming: Oscar Maddrell becomes triple British champion
Football: Mixed results for IoM Women in summer series