Leaders Geordies have the weekend off
With Canada Life Premier League leaders St. George's not playing, St. Mary's have the opportunity to move to within two points if they win their game in hand.
They welcome Old Boys to The Bowl in a match which kicks-off at 2.30pm.
All other matches start at two o'clock.
Third in the table Corinthians are at home to Laxey while fellow Railway Cup semi-finalists Peel visit Rushen in the "Old Firm" clash.
Elsewhere, St. John's host Ramsey, Union Mills tackle Douglas Athletic and Colby head north to Ayre.
FC Isle of Man and AFC Liverpool to meet in vital hunt for points
Hockey: Cup finals double-header on the cards
Rugby: Douglas to host Sandbach in big top-of-the-table clash
Football: Prem title contenders Corinthians and Peel to meet