FA Cup holders St Mary’s will host St George’s in a repeat of last year’s final.
In the other tie, Ramsey will meet Peel.
The semi-final draw was made live on Manx Radio on Saturday evening.
Paddy Power FA Cup semi-finals
St Mary’s v St George’s
Ramsey v Peel
Ravens looking to keep play-off hopes alive at Glossop North End
FC Isle of Man without an away win since November
Hockey: Castletown & Bacchas to maintain perfect prem starts?
Southern derby one of headline ties in Ladies Division One
Rugby: Third time lucky for Douglas vs Eccles?
Big double-header also on the cards at Ballafletcher
Football: Ecap FA Cup first round proper beckons
Women's Floodlit Cup second leg also awaits this weekend (Fixtures: 8-9 Feb)