Onchan surprised Ayre United in the GH Corlett Woods Cup preliminary round.
Craig Marsh, Mark Burman, Gerard Colligon and Mark Rees were on target in a 4-2 home win.
Phil Quayle and Elliot Cureton replied for the Tangerines.
Douglas Athletic are up to fifth in JCK Division Two after an 8-1 thrashing of Braddan.
A Josh Green treble, a Liam Dawson double and further goals from Darren Shields, Andy Newton and Stuart Monks (penalty) secured the three points to lift them above Colby in the table.
Charity to assist with Pre-TT Classic preparations
Beach Buddies set to clean entire Billown Course
McGuinness: TT is 'the journey that keeps on giving'
Twenty-three-time winner celebrating 30 years at the event in 2026
Football: Corinthians book place in Hospital Cup final
Ramsey Youth Centre & Old Boys win key Division 2 promotion clash
Rugby: A win and a defeat for national sides on the road
Manx teams make long-awaited return in friendlies against Warrington RUFC