Holders Peel at Ramsey
Having wrapped up yet another Premier League title, St. George's are halfway on the route to the Grand Slam.
They turn their attention to the Friends Provident International FA Cup and a visit to Division Two side Marown.
There are three all top-flight ties - Old Boys host St. Mary's, Corinthians travel to Rushen and holders Peel go to Ramsey.
Governor's Athletic have reached the last sixteen for the first time and go to Douglas Athletic.
Elsewhere, Douglas & District entertain Ramsey Youth Centre, Colby make the trip to Foxdale and Pulrose welcome Braddan.
TT 2026: Nathan Harrison to race again under H&H Motorcycles banner
Snooker: Hurricanes join PSM Legion at league summit
FC Isle of Man lose out at free-scoring Chadderton
TT 2026: DAO Racing returns with Josh Brookes at the helm