In Football, Premier League leaders Laxey have the week off so it gives their rivals a chance to catch up.
Second placed St. Mary's can close to within a point if they see off the challenge of fourth in the table Peel at The Bowl.
Champions St. George's face Corinthians.
In Rugby, Douglas, Ramsey and Vagabonds are all in South Lancashire and Cheshire Division Two.
And the Hockey Mixed Premier League opens with Champions Valkyrs "A" facing Vikings "A" at the National Sports Centre at 2.05pm.
Football: IoM women's team back in action this weekend
Island side will host FC United of Manchester at The Bowl
Triathlon: Will Draper victorious at Challenge Salou
Island competitor wins PRO Middle Distance event in Spain
Grant Thomson to race next week after new ankle diagnosis
Island rider says he has no fractures after NW200 crash
National rugby sides to make long-awaited return this weekend
Two Island teams to face Warrington RUFC