A 74-year-old man Douglas man died in the collision which occurred on the Mountain Road earlier today (Tuesday).
It happened at 10am at the Creg-ny-Baa.
Although witnesses have come forward to assist, police are eager to speak with any other witnesses who were in the area at the time.
The two vehicles involved were a Ramsey-bound silver and blue Smart car and a Douglas-bound black Vauxhall Zafira.
The deceased man’s details have not been released but his immediate family and the Coroner of Inquests have been informed.
John Wannenburgh: 'Commitment, compassion and an unwavering sense of duty'
Manx Utilities 'deeply saddened' by death of chairman
"Tynwald will be a less colourful place without John" says president
Douglas North MHK pays tribute to 'amazing friend'