A 74-year-old man Douglas man died in the collision which occurred on the Mountain Road earlier today (Tuesday).
It happened at 10am at the Creg-ny-Baa.
Although witnesses have come forward to assist, police are eager to speak with any other witnesses who were in the area at the time.
The two vehicles involved were a Ramsey-bound silver and blue Smart car and a Douglas-bound black Vauxhall Zafira.
The deceased man’s details have not been released but his immediate family and the Coroner of Inquests have been informed.
DoI seeking 'fair and sustainable' solution to bus drivers' dispute
Island gets 'bang for its buck' without a London office, says External Relations director
IOM taking pre-emptive moves as Middle East conflict continuesÂ
Two sailings cancelled due to weather forecast