Police are investigating large-scale damage to a building under construction on King Edward Road, Onchan.
Twenty-six ground floor windows were smashed some time between 5pm on Monday and 1pm on Tuesday.
Anybody with information is asked to ring Onchan Police Station on 675190 or Police Headquarters in Douglas on 631212.
Off-Island hospital spend £1.3m higher than expected
Manx Care says a number of factors have contributed
Thirteen Manx landmarks given protected status
Political sites, medieval bridges and Victorian railway buildings all feature
MGP/Classic TT may attract fewer people compared to TT, but 'demand does not change'
Fifteen cases presented to the emergency department
'Know your numbers' when it comes to blood pressure
Manx pharmacies to offer free checks to encourage better health