Police say a domestic incident where serious threats were issued has now been resolved.
Officers closed Douglas Head Road at around 7pm between South Quay and Fort Anne Road.
The incident, on Taubmann Terrace, saw a huge police presence including armed officers.
They spent some hours negotiating with a man inside a property.
The incident has now been resolved and one man arrested.
Assisted Dying Bill: Will it get royal assent?
Amendments due to be debated in Tynwald
Council leader hits out at lack of support for social housing on brownfield sites
Devon Watson questions why government funds are available to private developers but not local authorities
Local charity marks Learning Disability Awareness Week
Manx Mencap hoping to put its service users in the spotlight
MHK questions port security measures following 'recent events in Belfast'
Urgent question tabled for June's Tynwald sitting